FEASIBILITY STUDY TO EXAMINE DISCREPANCY RATES IN PRESPECIFIED AND REPORTED OUTCOMES IN ARTICLES SUBMITTED TO THE BMJ

Feasibility study to examine discrepancy rates in prespecified and reported outcomes in articles submitted to The BMJ

Objectives Adding, omitting or changing prespecified outcomes can result in bias because it increases the potential for unacknowledged or post hoc revisions of the planned analyses.Journals have adopted initiatives such as requiring the prospective registration of trials and the submission of study protocols to promote the transparency of reporting

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Fluorescence anisotropy assays for high throughput screening of compounds binding to lipid II, PBP1b, FtsW and MurJ

Abstract Lipid II precursor and its processing by a flippase and peptidoglycan polymerases are considered key hot spot targets for antibiotics.We have developed a fluorescent anisotropy (FA) assay using a unique and versatile probe (fluorescent lipid II) and monitored direct binding between lipid II vegetable glycerin for sale and interacting prote

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